Description

Glycochenodeoxycholic Acid-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses by correcting for variations in sample preparation and instrument performance. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and contract testing facilities engaged in precise metabolic profiling and biomarker discovery.

Application

• Internal Standard for LC-MS/MS quantification of bile acids in biological matrices (plasma, serum, urine).
• Metabolomics and biomarker research for studying liver function, cholestasis, and gastrointestinal disorders.
• Pharmacokinetic and drug metabolism studies in pharmaceutical development.
• Quality control and method validation in clinical diagnostic assay development.
• Stable Isotope Dilution Analysis (SIDA) for achieving high analytical precision.
• Research into Farnesoid X receptor (FXR) signaling pathways and related therapeutics.

Basic Information

Product Name	Glycochenodeoxycholic Acid-D4
CAS No.	1201918-16-2
Molecular Formula	C₂₆H₄₀D₄NO₆
Molecular Weight	474.66 g/mol (for unlabeled form; exact mass may vary)
Synonyms	Glycochenodeoxycholic Acid-d4; GCDCA-d4; N-[(3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine-d4; Chenodeoxycholylglycine-d4; Glycochenodeoxycholate-d4; Deuterated Glycochenodeoxycholic Acid; [D4]-Glycochenodeoxycholic Acid; Stable Isotope Labeled GCDCA
EINECS	Contact for details

Quality Control

Our Glycochenodeoxycholic Acid-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for reference materials, and custom QC packages are available to meet specific study protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by HPLC, area %)
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.