Description

Aminooxy-Peg3-Thiol is a heterobifunctional crosslinker featuring a terminal aminooxy group and a thiol group, connected by a triethylene glycol (PEG3) spacer. This compound is critical for creating stable, site-specific conjugations, particularly through oxime ligation with aldehydes or ketones, while the thiol enables additional coupling strategies. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise assembly of complex biomolecules and functional surfaces.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of payloads, dyes, or proteins to antibodies or other biomolecules via oxime bond formation.
• Surface Functionalization and Biosensor Fabrication: Immobilization of biomolecules onto gold or maleimide-activated surfaces for microarray and diagnostic device development.
• Polymer and Hydrogel Modification: Introduction of reactive handles into polymer backbones or hydrogel matrices for creating smart, responsive materials.
• Peptide and Protein Labeling: Selective modification of N-terminal serine or threonine residues (after periodate oxidation) or carbonyl-containing tags for imaging and tracking studies.
• Liposome and Nanoparticle Targeting: Conjugation of targeting ligands to nanoparticle surfaces for targeted drug delivery systems.
• Chemical Biology Tool Development: Synthesis of probes and reagents for studying protein function, interactions, and localization.

Basic Information

Product Name	Aminooxy-Peg3-Thiol
CAS No.	1200365-63-4
Molecular Formula	C11H23NO5S
Molecular Weight	281.37 g/mol
Synonyms	3-[2-[2-(2-Aminooxyethoxy)ethoxy]ethoxy]propane-1-thiol; Aminooxy-PEG3-thiol; O-(2-Aminoethyl)-O'-(3-mercaptopropyl)triethylene glycol; Aminooxy-PEG3-SH; Aminooxy-tri(ethylene glycol)-thiol; Thiol-PEG3-aminooxy; 1-Aminooxy-3-mercapto-2,5,8,11-tetraoxatridecane; 11-Aminooxy-3,6,9-trioxaundecane-1-thiol
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg3-Thiol is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure consistency and performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the stringent requirements for research and biopharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to oxidation and high volatility. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Aminooxy)	≥ 90%
Assay (Thiol)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.