Description

Omadacycline (Hydrochloride) CAS NO 1196800-39-1 is a novel, fully synthetic aminomethylcycline antibiotic belonging to the tetracycline class. It is valued for its broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens, including multidrug-resistant strains. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions developing next-generation antibacterial therapies to address critical unmet medical needs.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antibacterial injectable and oral dosage forms.
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical trials for novel antibiotic development.
• Antimicrobial Susceptibility Testing: Used in microbiological laboratories to prepare discs, strips, or solutions for in-vitro testing against resistant bacterial isolates.
• Mechanistic Studies: Employed in biochemical and pharmacological research to investigate protein synthesis inhibition and bacterial resistance mechanisms.
• Drug Discovery: Acts as a lead compound or comparator in medicinal chemistry programs aimed at developing new tetracycline derivatives.

Basic Information

Product Name	Omadacycline (Hydrochloride)
CAS No.	1196800-39-1
Molecular Formula	C29H40FN5O7 • HCl
Molecular Weight	626.12 g/mol (free base: 589.66 g/mol)
Synonyms	PTK 0796; Amadacycline Hydrochloride; (4S,4aS,5aR,12aS)-9-Fluoro-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide monohydrochloride; N-[(4S,4aS,5aR,12aS)-9-Fluoro-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]methylcarbamic acid hydrochloride; Omadacycline HCl; PTK0796 Hydrochloride
EINECS	Contact for details

Quality Control

Our Omadacycline (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting specifications suitable for pharmaceutical development. Certificates of Analysis (COA) detailing results from HPLC, NMR, and other pharmacopeial tests are provided to support regulatory submissions and ensure supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.