Description

Forodesine is a potent and selective purine nucleoside phosphorylase (PNP) inhibitor, representing a significant advancement in targeted therapeutic research. Its primary value lies in its ability to induce apoptosis in malignant T-cells by causing an intracellular accumulation of deoxyguanosine, offering a novel mechanism of action for specific cancers. This compound is essential for pharmaceutical R&D teams, clinical researchers, and manufacturers focused on developing treatments for T-cell malignancies, autoimmune disorders, and other conditions where PNP modulation is beneficial.

Application

• Pharmaceutical Active Ingredient (API): Core component in the development and manufacturing of targeted therapies for T-cell acute lymphoblastic leukemia (T-ALL) and cutaneous T-cell lymphoma (CTCL).
• Biochemical Research: A critical tool compound for studying purine salvage pathways, nucleotide metabolism, and T-cell biology in academic and institutional laboratories.
• Preclinical & Clinical Development: Used in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and as a reference standard in clinical trial material production.
• Oncology Drug Discovery: Serves as a lead structure or benchmark for designing next-generation PNP inhibitors and combination therapies.

Basic Information

Product Name	Forodesine
CAS No.	1191450-19-7
Molecular Formula	C₁₁H₁₅N₅O₄
Molecular Weight	281.27 g/mol
Synonyms	BCX-1777; Immucillin H; Forodesine Hydrochloride; (3R,4S)-1-[(9-Deaza-9-oxohypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol]; 7-[(3R,4S)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-one; PNP Inhibitor BCX-1777
EINECS	Contact for details

Quality Control

Our Forodesine is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical reference standards and API intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.