Description

Dspe-Peg-Mal Average M.W. 2000 is a heterobifunctional polyethylene glycol (PEG) derivative, a critical building block for advanced bioconjugation and nanomaterial synthesis. This compound matters because it enables the precise, site-specific crosslinking of biomolecules and particles, which is fundamental for creating stable, functional drug delivery systems and diagnostic agents. Pharmaceutical researchers, biotech developers, and advanced material scientists need it to develop next-generation therapeutics, including antibody-drug conjugates (ADCs), liposomal formulations, and PEGylated nanoparticles.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to antibodies via maleimide-thiol chemistry.
• Liposome & Nanoparticle Functionalization: Incorporation into lipid bilayers (via DSPE anchor) for PEGylation and subsequent attachment of targeting ligands (via maleimide group).
• Protein & Peptide PEGylation: Creating stable, long-circulating biotherapeutics by conjugating to cysteine residues.
• Surface Modification: Crafting bio-inert or functionalized coatings on sensors, chips, and medical devices.
• Crosslinking Reagent: For creating hydrogels or crosslinked protein assemblies with controlled architecture.
• Diagnostic Probe Conjugation: Attaching imaging agents (e.g., fluorophores, radiolabels) to antibodies or other targeting molecules.

Basic Information

Item	Details
Product Name	Dspe-Peg-Mal Average M.W. 2000
CAS No.	1190924-04-9
Molecular Formula	CnH2n+1(OCH2CH2)mO-Mal-DSPE (Variable based on PEG chain length)
Molecular Weight	Average ~2000 Da (PEG portion)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; DSPE-PEG(2000)-Maleimide; Maleimide-PEG2000-DSPE; DSPE-PEG-Mal; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] amide terminated with maleimide; Phospholipid-PEG-Maleimide; Mal-PEG-DSPE
EINECS	Contact for details

Quality Control

Our Dspe-Peg-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group integrity, NMR for structural confirmation, and mass spectrometry for molecular weight verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications to ensure the material meets the stringent requirements for research and pre-clinical development. Our quality commitment supports applications demanding high reproducibility and performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white solid/wax
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight (PEG)	2000 ± 10%
Maleimide Functionalization	≥ 90%
Water Content (KF)	≤ 1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.