Description

Gatifloxacin-D4 is a deuterium-labeled analog of the broad-spectrum fluoroquinolone antibiotic gatifloxacin, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities requiring precise quantification of gatifloxacin in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for gatifloxacin bioanalysis.
• Pharmacokinetic Studies: Enables accurate measurement of drug concentration-time profiles in plasma, serum, and tissues during ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Drug Metabolism Research: Used in metabolite identification and quantification studies to track the parent drug without isotopic interference.
• Clinical Trial Support: Critical for generating reliable bioanalytical data in clinical trials to assess drug safety and efficacy.
• Forensic and Anti-Doping Analysis: Supports precise quantification in forensic toxicology and sports anti-doping control for gatifloxacin.
• Veterinary Pharmaceutical Analysis: Applied in residue testing and pharmacokinetic studies of veterinary formulations containing gatifloxacin.
• Method Development and Validation: Serves as a key component in developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA, EMA guidelines).
• Environmental Fate Studies: Can be utilized as a tracer in research investigating the environmental persistence and breakdown of fluoroquinolone antibiotics.

Basic Information

Product Name	Gatifloxacin-D4
CAS No.	1190043-25-4
Molecular Formula	C19H18D4FN3O4
Molecular Weight	379.40 g/mol (for deuterated form)
Synonyms	1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid-d4; (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid-d4; AM-1155-d4; BMS-206584-d4; Gatifloxacin (methyl-d4); Gatifloxacin-d4 Internal Standard; Gatifloxacin (piperazine-2,2,3,3-d4)
EINECS	Contact for details

Quality Control

Our Gatifloxacin-D4 is manufactured under strict quality control protocols to ensure the high isotopic purity and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (typically ≥98% D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing lot-specific results are provided and can be tailored to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.