Description

o-Desmethyl Metoprolol-D5 is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This compound is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers for precise bioanalysis and method validation.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the accurate measurement of metoprolol and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/ADME Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) by correcting for matrix effects and instrument variability.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Used in clinical studies to monitor metoprolol levels in patients, ensuring therapeutic efficacy and safety.
• Metabolite Profiling & Identification: Aids in the structural elucidation and quantification of metoprolol's metabolic pathway products.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Forensic & Doping Control Analysis: Applied in specialized testing laboratories for the definitive identification and quantification of substances.

Basic Information

Product Name	o-Desmethyl Metoprolol-D5
CAS No.	1189981-81-4
Molecular Formula	C14H17D5NO3
Molecular Weight	272.36 g/mol (deuterated form)
Synonyms	1-(4-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol-d5; Metoprolol Acid Metabolite-d5; α-Hydroxymetoprolol-d5; H 119/66-d5; O-Desmethylmetoprolol-d5; Metoprolol Metabolite-d5; Lopressor Metabolite-d5; Betaloc Metabolite-d5
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Metoprolol-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with the stringent requirements of analytical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.