Description

n-Desethylamiodarone-D4 Hcl is a high-purity, isotopically labeled internal standard critical for modern analytical chemistry. This deuterated compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for the precise quantification of amiodarone and its metabolites.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of amiodarone and its metabolites in pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Method development and validation for drug metabolism and ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Supporting clinical trial sample analysis for antiarrhythmic drug development.
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs).
• Use in forensic and doping control analysis for precise measurement.

Basic Information

Product Name	n-Desethylamiodarone-D4 Hcl
CAS No.	1189960-80-2
Molecular Formula	C23H25D4I2NO3 • HCl
Molecular Weight	695.69 g/mol (for free base, approximate)
Synonyms	2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone-d4 Hydrochloride; Desethylamiodarone-d4 HCl; Deuterated Desethylamiodarone Hydrochloride; Amiodarone Metabolite D4 Internal Standard; N-Desethyl Amiodarone-d4 HCl; 4-Desethylamiodarone-d4 Hydrochloride; DEA-d4 HCl
EINECS	Contact for details

Quality Control

Every batch of n-Desethylamiodarone-D4 Hcl is manufactured and tested to meet the stringent requirements of analytical reference standard applications. Our quality assurance protocol includes verification of isotopic purity (D4 label), chemical purity, and structural identity. Certificates of Analysis (COA) are provided with each shipment, detailing results from HPLC, NMR, and MS analysis to ensure traceability and compliance with your method validation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.