Description

Thiol-Dpeg4-Amie CAS NO 1189760-69-7 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a thiol group at one terminus and an amine group at the other, separated by a tetraethylene glycol spacer. This compound is a critical reagent for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules, nanoparticles, and surfaces. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, advanced diagnostics, and materials science who require controlled and reproducible conjugation chemistry.

Application

• Bioconjugation and Protein Modification: Site-specific coupling of peptides, proteins, and antibodies for therapeutic and diagnostic applications.
• PEGylation Chemistry: Functionalizing drug molecules, nanoparticles, and surfaces with PEG chains to improve solubility, stability, and biocompatibility.
• Surface Functionalization: Creating reactive amine-terminated monolayers on gold or other metal surfaces via the thiol group for biosensor and microarray development.
• Hydrogel and Biomaterial Synthesis: Serving as a crosslinking agent in the formation of biocompatible hydrogels for tissue engineering and drug delivery systems.
• Antibody-Drug Conjugate (ADC) Linker: As a component in the design of cleavable or non-cleavable linkers for targeted cancer therapies.
• Nanoparticle Functionalization: Attaching targeting ligands or fluorescent dyes to quantum dots, liposomes, and polymeric nanoparticles.

Basic Information

Product Name	Thiol-Dpeg4-Amie
CAS No.	1189760-69-7
Molecular Formula	C15H31NO5S
Molecular Weight	337.48 g/mol
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecane-15-thiol; 15-Amino-4,7,10,13-tetraoxa-1-thiapentadecane; HS-PEG4-NH2; Thiol-PEG4-Amine; α-Thiol-ω-amino tetraethylene glycol; 2,5,8,11-Tetraoxatetradecane-14-thiol, 14-amino-; Amino-PEG4-thiol; Amine-PEG4-SH
EINECS	Contact for details

Quality Control

Our Thiol-Dpeg4-Amie is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Thiol Content (Titration)	≥ 90% of theoretical
Amine Content (Titration)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.