Description

N4-Acetylsulfapyridine-D4 is a stable isotope-labeled analog of the sulfonamide metabolite, N4-acetylsulfapyridine, where four hydrogen atoms are replaced by deuterium. This compound is of critical importance as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic manufacturers for pharmacokinetic studies, drug metabolism research, and clinical assay development.

Application

• Primary use as a deuterated internal standard for the precise quantification of sulfapyridine and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Essential for pharmacokinetic (PK) and drug metabolism studies involving sulfonamide antibiotics, enhancing data integrity and regulatory compliance.
• Critical component in the development and validation of clinical diagnostic assays for therapeutic drug monitoring (TDM).
• Used in stable isotope dilution analysis to correct for analyte loss during sample preparation and instrument variability.
• Supports forensic and toxicological analysis for the accurate detection of sulfonamides in complex samples.
• Valuable for academic and industrial research into the metabolic pathways and bioavailability of sulfa drugs.

Basic Information

Product Name	N4-Acetylsulfapyridine-D4
CAS No.	1189732-52-2
Molecular Formula	C13D4H11N3O3S
Molecular Weight	281.33 g/mol (deuterated form)
Synonyms	N4-Acetylsulfapyridine-d4; Deuterated N4-Acetylsulfapyridine; Sulfapyridine N4-acetate-d4; 4-Acetamido-N-(2-pyridinyl)benzenesulfonamide-d4; Acetylsulfapyridine-d4; N-(4-Sulfamoylphenyl)acetamide-d4; N1-Acetylsulfapyridine-d4; Internal Standard for Sulfapyridine
EINECS	Contact for details

Quality Control

Every batch of N4-Acetylsulfapyridine-D4 is manufactured and tested to meet the exacting standards required for analytical reference materials. Our products undergo rigorous quality testing, including isotopic purity and chemical purity verification, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for identity, assay, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.