Description

Dl-Nicotine-D3 is a deuterium-labeled isotopologue of nicotine, a key alkaloid, specifically designed for use as an internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in mass spectrometry, by correcting for variations in sample preparation and instrument response. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and toxicology sectors who require precise measurement of nicotine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of nicotine, cotinine, and related compounds in complex biological matrices like plasma, urine, and saliva.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of nicotine absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic Toxicology: Used in assays to determine nicotine exposure levels and validate testing methods for legal and workplace testing.
• Pharmaceutical R&D: Supports the development and bioanalysis of nicotine replacement therapies (NRTs) such as patches, gums, and lozenges.
• Environmental and Agricultural Analysis: Facilitates the detection and quantification of nicotine residues in environmental samples or agricultural products.
• Reference Material: Serves as a high-purity certified reference material (CRM) for method development, validation, and laboratory accreditation.

Basic Information

Product Name	Dl-Nicotine-D3
CAS No.	1189681-48-8
Molecular Formula	C₁₀H₁₁D₃N₂
Molecular Weight	165.24 g/mol
Synonyms	Nicotine-d3; (±)-Nicotine-d3; DL-Nicotine-d3; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine-d3; (RS)-Nicotine-d3; Nicotine (methyl-d3); 1-Methyl-2-(3-pyridyl)pyrrolidine-d3; Deuteronated Nicotine
EINECS	Contact for details

Quality Control

Our Dl-Nicotine-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific purity or enrichment specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.