Description

Rac-Naproxen-D3 Methyl Ester CAS NO 1189511-76-9 is a deuterated isotopologue of the naproxen methyl ester derivative, serving as a critical analytical standard and stable isotope-labeled intermediate. Its core value lies in enabling precise quantification and metabolic pathway tracing in complex biological matrices, ensuring data integrity for research and regulatory submissions. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on method development, bioanalytical studies, and pharmacokinetic research for non-steroidal anti-inflammatory drugs (NSAIDs).

Application

• Use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of naproxen and its metabolites.
• Critical reagent in deuterium-labeled drug synthesis for the development of new chemical entities or prodrugs.
• Employed in pharmacokinetic and metabolic stability studies to track drug disposition and identify metabolic soft spots.
• Essential for bioanalytical method validation according to FDA and ICH guidelines, ensuring specificity and accuracy.
• Used in doping control analysis and forensic toxicology to confirm the presence of naproxen.
• Application in environmental fate studies to trace pharmaceutical residues in water systems.

Basic Information

Product Name	Rac-Naproxen-D3 Methyl Ester
CAS No.	1189511-76-9
Molecular Formula	C15H15D3O3
Molecular Weight	249.31 g/mol (approx.)
Synonyms	(±)-2-(6-Methoxy-2-naphthyl)propionic-3,3,3-d3 Acid Methyl Ester; Methyl 2-(6-Methoxynaphthalen-2-yl)-3,3,3-trideuteriopropanoate; Naproxen Methyl Ester-d3; DL-Naproxen Methyl Ester-d3; Rac-Naproxen-d3 Methyl Ester; Naproxen-d3 Me ester; Methyl (RS)-2-(6-Methoxy-2-naphthyl)-3,3,3-trideuteriopropionate
EINECS	Contact for details

Quality Control

Every batch of Rac-Naproxen-D3 Methyl Ester is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure it meets the high-purity standards required for sensitive analytical applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity (deuterium incorporation), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our products undergo rigorous quality testing to ensure compliance with industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.