Description

1-Methyluric Acid-D3 is a stable isotope-labeled analog of 1-methyluric acid, where three hydrogen atoms are replaced by deuterium. This compound is of critical importance as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and precision in mass spectrometry-based analyses. It is primarily needed by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in metabolomics, pharmacokinetic studies, and the development of diagnostic assays for purine metabolism disorders.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial deuterated internal standard for the precise quantification of 1-methyluric acid and related purine metabolites in biological matrices like plasma, urine, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the metabolic pathways and clearance rates of xanthine derivatives and related pharmaceuticals.
• Clinical Diagnostics: Enables accurate measurement of purine metabolite levels for research into conditions such as gout, hyperuricemia, and Lesch-Nyhan syndrome.
• Biomarker Research: Facilitates the discovery and validation of purine-based biomarkers in various disease states through stable isotope dilution techniques.
• Method Development and Validation: Essential for developing robust, GLP-compliant analytical methods in regulatory bioanalysis.
• Quality Control in Reference Material Production: Used in the synthesis and certification of certified reference materials (CRMs) for clinical laboratories.

Basic Information

Product Name	1-Methyluric Acid-D3
CAS No.	1189480-64-5
Molecular Formula	C6H3D3N4O3
Molecular Weight	186.15 g/mol
Synonyms	1-Methyluric Acid-d3; [2,6,8-2H3]-1-Methyluric Acid; 1-Methyl-2,6,8-trideuterio-1H-purine-2,6,8(3H,7H,9H)-trione; Deuterated 1-Methyluric Acid; 1-MUA-d3; Internal Standard for 1-Methyluric Acid
EINECS	Contact for details

Quality Control

Our 1-Methyluric Acid-D3 is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure high chemical purity and isotopic enrichment, meeting the stringent requirements for analytical reference standards. Certificates of Analysis (COA) are provided, detailing results for assay, isotopic purity (D-enrichment), and key impurities by advanced techniques like NMR and HPLC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.