Description

Rac 5-Hydroxymethyl Desisopropyl Tolterodine-D6 is a deuterated isotopologue of a key intermediate in the synthesis of tolterodine and its related compounds. This high-purity reference standard is critical for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and development. It is primarily utilized by analytical chemists and quality control laboratories in the pharmaceutical industry for method development, validation, and as an internal standard in mass spectrometry.

Application

• Primary use as an Internal Standard (IS) for the quantitative analysis of tolterodine and its metabolites via LC-MS/MS and GC-MS.
• Critical reference material for pharmaceutical method development and validation to meet regulatory requirements (e.g., FDA, EMA).
• Used in metabolite identification and pharmacokinetic studies to track drug distribution and clearance.
• Essential component in impurity profiling and stability studies of tolterodine-based drug products.
• Supports forensic and anti-doping analysis where precise quantification of specific compounds is required.
• Valuable for academic and industrial research exploring the structure-activity relationships of muscarinic receptor antagonists.

Basic Information

Product Name	Rac 5-Hydroxymethyl Desisopropyl Tolterodine-D6
CAS No.	1189419-89-3
Molecular Formula	C21H25D6NO3
Molecular Weight	351.53 g/mol (Calculated)
Synonyms	5-(Hydroxymethyl)-α,α-bis(1-methylethyl)-2-[(1R)-1-phenyl-3-(2,2,2-trideuterio-1-hydroxyethyl)amino]propyl]benzenemethanol-d3; Desisopropyl Tolterodine D6 Hydroxymethyl Derivative; (Rac)-5-Hydroxymethyl Desisopropyl Tolterodine-d6; Tolterodine D6 Intermediate; N-Desisopropyl-5-hydroxymethyl Tolterodine-D6; 2-[(1R)-3-[(2,2,2-Trideuterio-1-hydroxyethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)-α,α-bis(1-methylethyl)benzenemethanol-d3
EINECS	Contact for details

Quality Control

Every batch of Rac 5-Hydroxymethyl Desisopropyl Tolterodine-D6 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of identity, purity, and isotopic enrichment. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to guarantee suitability for use as a certified reference material. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to in-house standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.