Description

Desmethyl Mirtazapine-D4 is a deuterium-labeled analog of the primary metabolite of the antidepressant mirtazapine. This stable isotope-labeled compound is essential for precise and reliable quantitative analysis in complex biological matrices. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors, ensuring accurate pharmacokinetic studies and bioanalytical method validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of mirtazapine and its metabolites.
• Critical component in pharmacokinetic and bioequivalence studies to determine drug absorption, distribution, metabolism, and excretion.
• Essential for forensic and clinical toxicology analysis to accurately measure drug concentrations in blood, plasma, or urine.
• Used in drug metabolism and disposition (DMPK) research to elucidate metabolic pathways.
• Supports pharmaceutical quality control and method development for assay validation.
• Valuable tool in academic and institutional research focused on neuropharmacology and analytical chemistry.

Basic Information

Product Name	Desmethyl Mirtazapine-D4
CAS No.	1188331-80-7
Molecular Formula	C₁₇H₁₄D₄N₃
Molecular Weight	270.36 g/mol
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyl-d4-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine; 6-Azamianserin-D4; Mirtazapine Metabolite D4; 8-Hydroxymirtazapine-D4 (related metabolite); Deuterated Desmethyl Mirtazapine; [D4]-Desmethyl Mirtazapine; N-Desmethyl Mirtazapine-d4
EINECS	Contact for details

Quality Control

Every batch of Desmethyl Mirtazapine-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results (NMR, HPLC, MS) is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.