Description

Raloxifene-D4, Hydrochloride CAS NO 1188263-47-9 is a deuterium-labeled analog of the selective estrogen receptor modulator (SERM) raloxifene hydrochloride. This stable isotope-labeled compound is an essential internal standard for the precise quantification of raloxifene in complex biological matrices using advanced analytical techniques. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Internal Standard: Used as a critical reference standard in LC-MS/MS and GC-MS methods for the accurate quantification of raloxifene in plasma, serum, and tissue samples.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control & Forensic Analysis: Employed in confirmatory testing for banned substances in sports and forensic toxicology investigations.
• Quality Control for Pharmaceutical Manufacturing: Used in in-process testing and final product release assays to ensure the potency and purity of raloxifene-based drug products.
• Stable Isotope Tracing: Facilitates metabolic pathway elucidation and mechanistic studies in endocrinology and oncology research.

Basic Information

Product Name	Raloxifene-D4, Hydrochloride
CAS No.	1188263-47-9
Molecular Formula	C28H23D4NO4S • HCl
Molecular Weight	528.09 g/mol (for free base C28H23D4NO4S)
Synonyms	Raloxifene-d4 HCl; [2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone-d4 Hydrochloride; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl-4-[2-(1-piperidinyl)ethoxy]phenyl methanone-d4 Hydrochloride; LY-156758-d4 Hydrochloride; Keoxifene-d4 Hydrochloride; Evista-d4 (labeled analog); Deuterated Raloxifene Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Raloxifene-D4, Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity, chemical purity, and structural identity. Our quality commitment aligns with the needs of regulated bioanalysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests including HPLC assay, isotopic enrichment (by MS), chiral purity, residual solvent analysis, and identity confirmation (by NMR and IR).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.