Description

(1R,2S,3R)-Aprepitant is a specific stereoisomer of the neurokinin-1 (NK1) receptor antagonist aprepitant, identified by CAS NO 1185502-97-9. This compound is a critical chiral intermediate or reference standard in the research and development of antiemetic pharmaceuticals, particularly for chemotherapy-induced nausea and vomiting (CINV). It is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on stereoselective synthesis, process development, and quality control of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the NK1 receptor antagonist aprepitant and its analogs.
• Reference Standard: Used as a high-purity standard for analytical methods, including HPLC and chiral chromatography, to ensure product identity and purity.
• Process Research & Development (R&D): Employed in route scouting and optimization for the stereoselective manufacture of active pharmaceutical ingredients (APIs).
• Metabolite Studies: Utilized in pharmacological and pharmacokinetic research to study drug metabolism and stereoisomer activity.
• Quality Control (QC) Testing: Serves as a critical component in impurity profiling and assay validation for pharmaceutical quality assurance.

Basic Information

Product Name	(1R,2S,3R)-Aprepitant
CAS No.	1185502-97-9
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(3R)-1-[3,5-Bis(trifluoromethyl)benzyl]-5-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one; (1R,2S,3R)-Fosaprepitant Impurity; Aprepitant Stereoisomer; Aprepitant Related Compound; L-754030 Stereoisomer; MK-0869 Stereoisomer; Emend Intermediate
EINECS	Contact for details

Quality Control

Our (1R,2S,3R)-Aprepitant is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure compliance with high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions if the container is opened repeatedly to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.