Description

Cimetidine-D3 CAS NO 1185237-29-9 is a deuterium-labeled isotopologue of the well-known histamine H₂-receptor antagonist, cimetidine. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing unmatched precision in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in developing and validating sensitive LC-MS/MS methods for drug analysis.

Application

• Used as an internal standard in the quantitative analysis of cimetidine and its metabolites via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Critical for conducting pharmacokinetic (PK) and bioavailability studies in both preclinical and clinical research settings.
• Enables accurate drug metabolism and disposition (DMPK) investigations, helping to elucidate metabolic pathways.
• Supports bioequivalence testing for generic drug development and regulatory submissions.
• Facilitates high-precision therapeutic drug monitoring (TDM) in clinical chemistry.
• Employed in forensic and toxicological analysis for the definitive identification and quantification of cimetidine.

Basic Information

Product Name	Cimetidine-D3
CAS No.	1185237-29-9
Molecular Formula	C₁₀H₁₃D₃N₆S
Molecular Weight	255.34 g/mol
Synonyms	1-Cyano-2-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-D3-guanidine; [2H3]-Cimetidine; Cimetidine (methyl-D3); Deuterated Cimetidine; SKF 92334-D3; N''-Cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-D3-guanidine
EINECS	Contact for details

Quality Control

Every batch of Cimetidine-D3 is manufactured and tested to meet the stringent requirements for stable isotope-labeled internal standards. Our quality assurance includes rigorous analysis for isotopic purity, chemical purity, and structural confirmation. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from NMR, HPLC, and MS. We adhere to cGMP principles for research chemicals to ensure traceability, consistency, and reliability for your critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.