Description

Etretinate-D3 is a deuterium-labeled isotopologue of the synthetic retinoid etretinate, serving as a critical internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring definitive standardization for complex bioanalytical assays.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the accurate quantification of etretinate and its metabolites in biological matrices (plasma, serum, tissue).
• Pharmacokinetic Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Metabolite Identification and Profiling: Assists in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry analysis.
• Bioanalytical Method Development and Validation: A key component in developing robust, sensitive, and regulatory-compliant (FDA, EMA) bioanalytical assays.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Provides essential data for understanding the in vivo behavior of retinoid-based therapeutics.
• Quality Control in Reference Material Production: Used to certify and validate the purity and concentration of etretinate reference standards.

Basic Information

Product Name	Etretinate-D3
CAS No.	1185237-13-1
Molecular Formula	C23H27D3O3
Molecular Weight	357.50 g/mol (approx.)
Synonyms	Etretinate-d3; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid ethyl ester-d3; Ethyl (all-E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate-d3; Ro 10-9359-d3; Tigason-d3; Isotopically Labeled Etretinate; Deuterated Etretinate Internal Standard
EINECS	Contact for details

Quality Control

Our Etretinate-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.