Description

n-(2-Maleimidoethyl)-6-Aminohexanamide, Trifluoroacetic Acid Salt is a high-purity, heterobifunctional crosslinking reagent designed for advanced bioconjugation. Its core value lies in enabling the precise and stable attachment of biomolecules, such as antibodies or peptides, to surfaces, particles, or other proteins. This compound is essential for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science who require reliable and efficient conjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate for constructing stable, cleavable, or non-cleavable linkers connecting cytotoxic drugs to monoclonal antibodies.
• Protein and Peptide Immobilization: Used to functionalize sensor chips (e.g., for SPR), microplates, or chromatography resins by covalently binding proteins via amine or sulfhydryl groups.
• Nanoparticle and Biomaterial Functionalization: Enables the surface modification of quantum dots, liposomes, or polymeric nanoparticles with targeting ligands for therapeutic or diagnostic applications.
• Crosslinking for Structural Biology: Employed in studying protein-protein interactions and complex structures through chemical crosslinking mass spectrometry (XL-MS).
• Diagnostic Reagent Development: Critical for conjugating enzymes, fluorophores, or haptens to antibodies or antigens in ELISA, lateral flow assays, and other immunoassays.
• Polymer Modification: Used to introduce reactive maleimide groups into polymers or hydrogels for subsequent bioconjugation in tissue engineering or drug delivery systems.

Basic Information

Product Name	n-(2-Maleimidoethyl)-6-Aminohexanamide, Trifluoroacetic Acid Salt
CAS No.	1185075-13-1
Molecular Formula	C15H22F3N3O5
Molecular Weight	381.35 g/mol
Synonyms	6-[(2-Maleimidoethyl)amino]hexanamide Trifluoroacetate; Maleimide-PEG2-Ahx-NH2 TFA Salt; SM(PEG)2 Amine TFA Salt; N-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-6-aminohexanamide Trifluoroacetic Acid Salt; 1H-Pyrrole-1-hexanamide, 2,5-dihydro-2,5-dioxo-1-[2-[(6-aminohexanoyl)amino]ethyl]-, trifluoroacetate; Heterobifunctional PEG Crosslinker (amine and maleimide); Amine-PEG2-Maleimide TFA Salt; LC-SMCC Amine Analog TFA Salt
EINECS	Contact for details

Quality Control

Our n-(2-Maleimidoethyl)-6-Aminohexanamide, Trifluoroacetic Acid Salt is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ISO 9001 and ICH Q7 guidelines, and our quality protocols are designed to meet the stringent requirements of biopharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH limits
Trifluoroacetic Acid Content	10 - 15% (by NMR/HPLC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.