Description

iso-Nnal-D3 CAS NO 1184990-35-9 is a deuterium-labeled isotopologue of a key naltrexone metabolite, specifically designed for use as an internal standard in advanced analytical applications. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors who require precise and interference-free measurement of naltrexone and its derivatives.

Application

• Primary use as an Internal Standard for the quantification of naltrexone and its metabolites via LC-MS/MS and GC-MS.
• Metabolite profiling and pharmacokinetic studies in drug development and clinical research.
• Forensic and clinical toxicology analysis for accurate determination of opioid antagonist levels.
• Supporting bioanalytical method development and validation to meet regulatory guidelines (e.g., FDA, EMA).
• Use in doping control analysis within sports anti-doping programs.
• Research into the metabolic pathways and stability of opioid antagonists.

Basic Information

Product Name	iso-Nnal-D3
CAS No.	1184990-35-9
Molecular Formula	C20H20D3NO4
Molecular Weight	344.43 g/mol
Synonyms	6β-Naltrexol-d3; 6β-Naltrexol (phenyl-d3); 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one-d3; Deuterated 6β-Naltrexol; 6β-Naltrexol Internal Standard; iso-6β-Naltrexol-d3; Naltrexone Metabolite-d3
EINECS	Contact for details

Quality Control

Our iso-Nnal-D3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm identity, isotopic purity (deuterium incorporation), and chemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ISO standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.