Description

Cyclobenzaprine-D3 Hcl CAS NO 1184983-42-3 is a deuterium-labeled analog of the centrally-acting skeletal muscle relaxant, cyclobenzaprine hydrochloride. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of cyclobenzaprine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioanalytical Studies: Enables accurate determination of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and non-clinical research.
• Drug Metabolism Research: Used to investigate metabolic pathways and identify metabolites, supporting drug safety and efficacy evaluations.
• Forensic and Clinical Toxicology: Assists in the reliable detection and measurement of cyclobenzaprine in forensic analysis and therapeutic drug monitoring.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product quality assurance.

Basic Information

Product Name	Cyclobenzaprine-D3 Hcl
CAS No.	1184983-42-3
Molecular Formula	C20H18D3N•HCl
Molecular Weight	Approx. 318.9 g/mol
Synonyms	Cyclobenzaprine-d3 hydrochloride; 5-(3-Dibenzocycloheptenylidene)-1,1-dimethyl-3-(trideuteriomethyl)piperidine hydrochloride; 1,1-Dimethyl-3-(trideuteriomethyl)-5-(3H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine hydrochloride; Cyclobenzaprine (methyl-d3) hydrochloride; Cyclobenzaprine D3 HCl; Deuterated Cyclobenzaprine HCl; Cyclobenzaprine Internal Standard; [2H3]-Cyclobenzaprine hydrochloride
EINECS	Contact for details

Quality Control

Our Cyclobenzaprine-D3 Hcl is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for assay, isotopic enrichment, and related substances. Our quality commitment aligns with the standards expected for research chemicals in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D3)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.