Description

7-Methyluric Acid-13C4,15N3 is a stable isotope-labeled analog of 7-methyluric acid, a key metabolite in purine catabolism. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical measurements. It is primarily required by researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and metabolomics sectors for precise pharmacokinetic studies, biomarker validation, and method development.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of 7-methyluric acid and related purine metabolites in complex biological matrices.
• Pharmacokinetic and Drug Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the metabolic fate of purine-based pharmaceuticals.
• Clinical Diagnostics and Biomarker Research: Enables precise measurement of metabolite levels in urine, plasma, and serum for studies related to oxidative stress, gout, and other metabolic disorders.
• Metabolomics and Proteomics: A vital tool in high-throughput screening and profiling to understand metabolic pathways and disease mechanisms.
• Method Development and Validation: Provides a stable isotopic reference for developing and validating robust, GLP-compliant analytical methods in regulated environments.
• Quality Control and Reference Standards: Used by manufacturers of in-vitro diagnostic kits and certified reference material producers to ensure assay accuracy and traceability.

Basic Information

Product Name	7-Methyluric Acid-13C4,15N3
CAS No.	1173023-20-5
Molecular Formula	C413C3H6N15N2O3
Molecular Weight	~199.09 g/mol
Synonyms	1,7-Dimethyluric Acid-13C4,15N3; 7-Methyl-1H-purine-2,6,8(3H)-trione-13C4,15N3; 7-Methyl-1H,3H,7H-purine-2,6,8-trione-13C4,15N3; Isotopically Labeled 7-Methyluric Acid; [13C4,15N3]-7-Methyluric Acid; 7-Methyluric Acid (13C4,15N3); 7-Methyluric Acid-13C4,15N3 Internal Standard; 7-Methyluric Acid-d0 (Isotope Labeled)
EINECS	Contact for details

Quality Control

Every batch of 7-Methyluric Acid-13C4,15N3 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical identity. Certificates of Analysis (COA) detailing lot-specific results for purity, isotopic abundance, and solvent content are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (NMR)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.