Description

Propargyl-Peg5-Ch2Co2-Nhs is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and an NHS ester for efficient amine conjugation. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials with precise control over architecture and spacing. It is primarily utilized by researchers and developers in bioconjugation, pharmaceutical development, and advanced materials science for applications ranging from drug delivery systems to surface functionalization.

Application

• Bioconjugation and Protein/Peptide Labeling: NHS ester reacts with lysine residues to attach PEG spacers and propargyl handles for subsequent click chemistry modifications.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker component for attaching cytotoxic payloads to antibodies via amine coupling and click chemistry.
• Surface Functionalization: Used to modify amine-coated surfaces (e.g., glass, magnetic beads) with alkyne groups for immobilizing azide-tagged biomolecules or polymers.
• Polymer and Dendrimer Synthesis: Acts as a building block for constructing complex, branched polymeric architectures through sequential click and amidation reactions.
• Diagnostic Reagent Preparation: Facilitates the creation of fluorescent or detection probes by linking targeting molecules (amines) to reporter tags (azides).
• Hydrogel and Biomaterial Engineering: Incorporated into polymer backbones to introduce cross-linking points via click chemistry for tunable material properties.
• Lipid Nanoparticle (LNP) and Micelle Modification: Conjugates to amine-containing lipids or polymers to introduce alkyne functionality for further ligand attachment.
• Small Molecule Prodrug Synthesis: Enables the PEGylation of amine-containing drug molecules to improve solubility and pharmacokinetics.

Basic Information

Product Name	Propargyl-Peg5-Ch2Co2-Nhs
CAS No.	1161883-51-7
Molecular Formula	C26H43NO13
Molecular Weight	577.62 g/mol
Synonyms	Propargyl-PEG5-acid NHS ester; 5k-PEG4-Propargyl-acid NHS ester; NHS ester of Propargyl-PEG5-carboxylic acid; α-Propargyl-ω-NHS-PEG5; N-Hydroxysuccinimide ester of Propargyl-Pentaethylene glycol-carboxylic acid; Propargyl-PEG5-NHS; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Ch2Co2-Nhs is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oily solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.