Description

1,2-Dicholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid derivative engineered for advanced research and formulation applications. This compound is valued for its unique structural combination of a phosphocholine head group and dual cholesterylhemisuccinate moieties, which imparts specific membrane-interactive and delivery-enhancing properties. It is primarily utilized by researchers and product developers in the pharmaceutical, biotechnology, and advanced material science sectors for creating specialized liposomal and lipid-based delivery systems.

Application

• Liposomal Drug Delivery: A key component in the formulation of sterically stabilized or targeted liposomes for the encapsulation and delivery of therapeutic agents.
• Biomimetic Membrane Research: Used to construct model membrane systems for studying lipid raft dynamics, membrane protein interactions, and cellular signaling processes.
• Gene Delivery Vectors: Incorporated into non-viral transfection reagents and lipid nanoparticles (LNPs) to enhance stability and cellular uptake of nucleic acids.
• Diagnostic Agent Formulation: Serves as a structural lipid in the development of contrast agents and other diagnostic tools for medical imaging.
• Cosmetic & Dermal Delivery Systems: Employed in advanced cosmetic formulations to improve the skin penetration and stability of active ingredients.
• Vaccine Adjuvant Development: Investigated as a component in novel adjuvant systems to modulate immune responses.

Basic Information

Product Name	1,2-Dicholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine
CAS No.	1155878-69-5
Molecular Formula	C96H172NO10P
Molecular Weight	1511.4 g/mol (approx.)
Synonyms	Dicholesteryl Hemisuccinoyl Phosphatidylcholine; DC-HSPC; 1,2-Di-O-(cholesterylhemisuccinoyl)-sn-glycero-3-phosphocholine; Cholesterylhemisuccinate Phosphatidylcholine Derivative; Lipid 1155878-69-5; HSPC-Cholesterol Conjugate; Phospholipid-Cholesterol Hybrid Lipid
EINECS	Contact for details

Quality Control

Our 1,2-Dicholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and cGMP-guided development work. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.