Description

(R,R,R)-Aprepitant is a specific stereoisomer of the neurokinin-1 (NK1) receptor antagonist aprepitant, identified by CAS NO 1148113-53-4. This enantiomerically pure compound is of significant interest in advanced pharmaceutical research and development, particularly for investigating structure-activity relationships and receptor selectivity. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel therapeutic agents for central nervous system disorders and chemotherapy-induced nausea and vomiting (CINV).

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development and validation in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the research-scale synthesis of enantiomerically pure NK1 receptor antagonists.
• Medicinal Chemistry Research: A key building block for studying the pharmacological profile and metabolic pathways of specific aprepitant stereoisomers.
• Process Chemistry Development: Employed in optimizing asymmetric synthesis routes and chiral separation techniques for scale-up.
• Academic Research: Utilized in university and institutional labs for neuropharmacology studies and receptor binding assays.
• Regulatory Submissions: Provides essential data for investigational new drug (IND) and new drug application (NDA) filings concerning chiral purity.

Basic Information

Product Name	(R,R,R)-Aprepitant
CAS No.	1148113-53-4
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(3R,4R,5R)-5-[(2R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-3-(4-morpholinylmethyl)-2-oxo-1,2-dihydro-1H-1,4-benzodiazepine; (R,R,R)-Aprepitant; Aprepitant (R,R,R)-isomer; L-754030 (R,R,R)-isomer; MK-0869 (R,R,R)-isomer; (3R,4R,5R)-Aprepitant; (R,R,R)-MK-0869
EINECS	Contact for details

Quality Control

Our (R,R,R)-Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing results for chiral purity (HPLC), assay, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.