Description

n-[4-Amino-2-Chloro-6-[(2-Deoxy-2-Fluoro-β-D-Arabinopyranosyl)Amino]-5-Pyrimidinyl]-Formamide is a sophisticated nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. This compound matters due to its role as a key building block in the synthesis of novel antiviral and anticancer therapeutics, where precise molecular structure is critical for biological activity. It is primarily needed by R&D laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the development of next-generation nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleotide analogs.
• Antiviral Drug Research: Used in the R&D of therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Probe Development: Utilized to create labeled or modified nucleotides for studying enzyme mechanisms and cellular processes.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for fundamental studies in medicinal chemistry and nucleoside science.

Basic Information

Item	Details
Product Name	n-[4-Amino-2-Chloro-6-[(2-Deoxy-2-Fluoro-β-D-Arabinopyranosyl)Amino]-5-Pyrimidinyl]-Formamide
CAS No.	1140251-33-7
Molecular Formula	C₁₀H₁₃ClFN₅O₄
Molecular Weight	321.69 g/mol
Synonyms	4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-β-D-arabinopyranosyl)amino]-5-pyrimidinecarboxamide; 2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl-2,6-diamino-4-chloropyrimidine-5-carboxamide; 2'-F-ara-Nucleoside Intermediate; 2-Fluoro-2-deoxyarabinofuranosyl nucleoside analog; 4-Chloro-2,6-diamino-5-carboxamidopyrimidine arabinoside derivative; Clofarabine related intermediate; Fluorinated arabinonucleoside building block
EINECS	Contact for details

Quality Control

Our n-[4-Amino-2-Chloro-6-[(2-Deoxy-2-Fluoro-β-D-Arabinopyranosyl)Amino]-5-Pyrimidinyl]-Formamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.