Description

α-Maleimidopropionyl-ω-Succinimidyl-6(Ethylene Glycol) is a heterobifunctional crosslinker featuring a maleimide group and an NHS ester, connected by a hydrophilic polyethylene glycol (PEG) spacer. This compound is essential for creating stable, site-specific conjugations between thiol-containing molecules (like antibodies or peptides) and primary amine-containing targets. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein labeling, enabling the production of next-generation therapeutics and diagnostics.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via thiol and amine groups.
• Protein-Protein/Peptide Conjugation: Crosslinking of different biomolecules to create bispecific constructs or study protein interactions.
• Fluorescent or Biotin Labeling of Proteins/Antibodies: Attaching dyes, enzymes, or biotin to biomolecules for imaging, detection, and diagnostic assays.
• Surface Functionalization: Immobilization of proteins, peptides, or other ligands onto amine-functionalized surfaces (e.g., biosensors, microarrays).
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to improve the solubility, stability, and pharmacokinetics of therapeutic molecules.
• Nanoparticle Conjugation: Linking targeting ligands (like antibodies) to nanoparticles for targeted drug delivery or imaging.

Basic Information

Product Name	α-Maleimidopropionyl-ω-Succinimidyl-6(Ethylene Glycol)
CAS No.	1137109-21-7
Molecular Formula	C₂₃H₃₃N₃O₁₂
Molecular Weight	543.52 g/mol
Synonyms	Maleimide-PEG6-NHS ester; NHS-PEG6-Maleimide; SM(PEG)6; 6-(Maleimidopropionamido)hexanoic acid N-hydroxysuccinimide ester; Succinimidyl 6-((3-maleimidopropionamido)hexanoate); PEG6 crosslinker; Heterobifunctional PEG linker; Amine-to-thiol crosslinker; mPEG6-NHS ester
EINECS	Contact for details

Quality Control

Our α-Maleimidopropionyl-ω-Succinimidyl-6(Ethylene Glycol) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity. We support development and cGMP manufacturing needs with documentation traceability.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and the functional groups are susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.