Description

Tigecycline (Mesylate) CAS NO 1135871-27-0 is a glycylcycline antibiotic, a semi-synthetic derivative of minocycline. It is a critical pharmaceutical active ingredient valued for its broad-spectrum activity against multidrug-resistant Gram-positive and Gram-negative pathogens. This compound is essential for manufacturers in the pharmaceutical industry developing injectable antibiotic formulations for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient (API) in sterile injectable formulations.
• Antibiotic Drug Development: Serves as a key intermediate in the research and development of novel antibiotic therapies.
• Hospital-Use Injectable Solutions: Manufacture of finished dosage forms for intravenous administration in clinical settings.
• Combination Therapies: Potential use in combination with other agents for enhanced efficacy against resistant infections.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and verification.
• Microbiological Research: Employed in in-vitro studies to investigate mechanisms of action and resistance patterns.

Basic Information

Product Name	Tigecycline (Mesylate)
CAS No.	1135871-27-0
Molecular Formula	C29H39N5O8 • CH4O3S
Molecular Weight	585.65 g/mol (as free base: 585.65)
Synonyms	Tigecycline Mesylate; (4S,4aS,5aR,12aS)-9-[2-(tert-Butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide methanesulfonate; GAR-936; Wyeth 57273; Tygacil (brand name); Glycylcycline antibiotic
EINECS	Contact for details

Quality Control

Our Tigecycline (Mesylate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange amorphous powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Bacterial Endotoxins	< 0.5 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.