Description

Ac-Lys-Gln-Lys-Leu-Arg-Amc CAS NO 1135686-31-5 is a synthetic, fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critical for researchers and developers requiring precise measurement of specific protease activity in complex biological systems. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit development for studying enzyme kinetics and inhibitor screening.

Application

• Protease Activity Assays: As a fluorogenic substrate for measuring the activity of specific proteases, including trypsin-like enzymes.
• Drug Discovery & Development: High-throughput screening (HTS) of potential protease inhibitors in pharmaceutical research.
• Biochemical Research: Kinetic studies and characterization of enzyme mechanisms and specificity in academic and industrial laboratories.
• Diagnostic Development: A key component in the development of sensitive in-vitro diagnostic (IVD) tests for clinical analysis.
• Cell Biology Studies: Monitoring protease activity in cell-based assays and signaling pathway analysis.
• Quality Control in Biologics: Potentially used in QC testing for biopharmaceuticals where specific protease activity must be controlled.

Basic Information

Product Name	Ac-Lys-Gln-Lys-Leu-Arg-Amc
CAS No.	1135686-31-5
Molecular Formula	C38H64N12O9
Molecular Weight	833.0 g/mol (approximately)
Synonyms	Ac-KQKLR-AMC; Acetyl-Lys-Gln-Lys-Leu-Arg-7-Amino-4-methylcoumarin; Ac-Lys-Gln-Lys-Leu-Arg-AMC; Fluorogenic Peptide Substrate 1135686-31-5; Ac-KQKLR-AMC trifluoroacetate salt; Protease Substrate V; 7-Amino-4-methylcoumarin labeled peptide
EINECS	Contact for details

Quality Control

Every batch of Ac-Lys-Gln-Lys-Leu-Arg-Amc is produced and tested under stringent quality management systems. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.