Description

7’-o-(4,4’-Dimethoxytrityloxy)Morpholino Uracil is a specialized nucleoside phosphoramidite derivative, a critical building block in oligonucleotide synthesis. This high-purity intermediate is essential for the automated solid-phase synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids. It is primarily used by pharmaceutical R&D departments, biotechnology companies, and CROs engaged in the development of advanced genetic medicines and molecular diagnostics.

Application

• Oligonucleotide Synthesis: Key phosphoramidite monomer for the automated synthesis of morpholino-based antisense oligonucleotides (PMOs).
• Therapeutic Development: Production of research and GMP-grade intermediates for siRNA, antisense, and other gene-silencing therapeutic candidates.
• Molecular Biology Research: Synthesis of custom probes and primers for genetic analysis and diagnostic assay development.
• Pre-clinical & Clinical Manufacturing: Sourcing of high-quality building blocks for the scale-up and cGMP manufacturing of oligonucleotide APIs.
• Contract Research & Manufacturing (CRO/CMO): Reliable raw material for service providers specializing in nucleic acid synthesis.

Basic Information

Product Name	7’-o-(4,4’-Dimethoxytrityloxy)Morpholino Uracil
CAS No.	1127343-02-5
Molecular Formula	C34H35N3O8
Molecular Weight	613.66 g/mol
Synonyms	DMTr-Morpholino-U Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-morpholino-uridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); Morpholino Uracil DMT Phosphoramidite; PMO U Phosphoramidite; Uracil Morpholino Monomer DMT Protected; Antisense Morpholino Building Block; Gene Tools Morpholino Intermediate; 7'-O-DMT-morpholino-uridine CE phosphoramidite
EINECS	Contact for details

Quality Control

Our 7’-o-(4,4’-Dimethoxytrityloxy)Morpholino Uracil is manufactured under strict quality systems to ensure consistency and reliability for sensitive oligonucleotide synthesis. Each batch is characterized and tested to meet exacting standards for purity and identity, critical for high-yield coupling efficiency. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.