Description

Fmoc-Tyr(Tbu)-Bt CAS NO 1126433-42-8 is a protected tyrosine derivative, specifically an Fmoc-amino acid active ester, designed for high-efficiency peptide synthesis. This compound is a critical building block for solid-phase peptide synthesis (SPPS), offering superior coupling efficiency and reduced racemization risk. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic laboratories developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the efficient, sequential coupling of amino acids in automated and manual peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Bioconjugation: Serves as a linker or modifying agent for attaching peptides to other molecules, surfaces, or carriers in drug delivery systems.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable manufacture of bespoke peptide sequences.

Basic Information

Product Name	Fmoc-Tyr(Tbu)-Bt
CAS No.	1126433-42-8
Molecular Formula	C29H28N2O5
Molecular Weight	484.55 g/mol
Synonyms	Fmoc-O-tert-butyl-L-tyrosine benzotriazolyl ester; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine benzotriazole ester; Fmoc-Tyr(O-t-Bu)-OBt; Fmoc-L-Tyrosine(O-t-butyl)-OBt ester; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}-O-(tert-butyl)-L-tyrosyl)benzotriazole; Fmoc-Tyr(tBu)-OBt; Fmoc-Tyr(tBu)-Benzotriazole Ester
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Tbu)-Bt is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term stability, keep the material dry and under nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.