Description

Fmoc-Thr(Tbu)-Bt CAS NO 1126433-39-3 is a protected amino acid derivative, specifically an Fmoc-protected threonine with a tert-butyl side chain and activated as a benzotriazole ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering high coupling efficiency and minimal racemization. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key activated ester for the efficient, sequential incorporation of protected threonine into growing peptide chains.
• Pharmaceutical Intermediate: For the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used in the site-specific modification of proteins, antibodies, and other biomolecules to create conjugates for targeted therapies.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: Fundamental reagent for studying peptide structure, function, and interactions in biochemistry and molecular biology labs.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable synthesis of bespoke peptides for clients.

Basic Information

Product Name	Fmoc-Thr(Tbu)-Bt
CAS No.	1126433-39-3
Molecular Formula	C27H33N3O5
Molecular Weight	479.57 g/mol
Synonyms	Fmoc-Thr(OtBu)-OBt; Fmoc-O-tert-butyl-threonine benzotriazolyl ester; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine benzotriazole ester; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}-O-tert-butyl-L-threonyl)-1H-benzotriazole; Fmoc-L-threonine(O-t-butyl)-OBt ester; Fmoc-Thr(tBu)-OBt; Fmoc-T(tBu)-OBt; Fmoc-O-t-butyl-threonine-OBt
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Tbu)-Bt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below in a dry, well-ventilated area. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.