Description

Una-G(Ibu)-Ce Phosphoramidite is a specialized, high-purity phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is critical for introducing modified nucleosides into DNA or RNA sequences, enabling advanced research and therapeutic development. It is essential for pharmaceutical R&D, diagnostic assay development, and academic research focused on antisense oligonucleotides, siRNA, and aptamers. The product is supplied under stringent quality control to ensure optimal coupling efficiency and batch-to-batch consistency.

Application

• Oligonucleotide Synthesis: Key building block for the automated solid-phase synthesis of modified DNA and RNA strands.
• Therapeutic Oligonucleotide Development: Used in the research and production of antisense, siRNA, and aptamer-based drugs.
• Diagnostic Probe Manufacturing: For creating labeled or modified probes used in PCR, FISH, and microarray technologies.
• Academic & Industrial R&D: Enables studies on nucleic acid structure, function, and protein interactions.
• Synthesis of Modified Nucleosides: Facilitates the incorporation of specific functional groups or labels into oligonucleotide sequences.
• Scale-up & GMP Production: Suitable for process development and cGMP manufacturing of oligonucleotide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Una-G(Ibu)-Ce Phosphoramidite
CAS No.	1120329-61-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(Isobutyryl)(cyanoethyl)phosphoramidite] Guanosine; Una-G(Ibu)-CE Phosphoramidite; DMTr-G(Ibu)-CE Phosphoramidite; 2'-Deoxyguanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-[[[[2-cyanoethoxy)(diisopropylamino)phosphino]oxy]isobutyrate]; Guanosine Phosphoramidite (Ibu, DMT, CE); Ibu-G(DMT)-CE Phosphoramidite; N2-Isobutyryl-5'-O-DMT-2'-deoxyguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
EINECS	Contact for details

Quality Control

Our Una-G(Ibu)-Ce Phosphoramidite is manufactured under strict quality systems to meet the exacting standards of oligonucleotide synthesis. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure high coupling efficiency and reproducibility. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance, supporting both research and cGMP-compliant production workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and easily oxidized nature, the material should be brought to room temperature in a desiccator before opening to prevent condensation and degradation. For long-term stability, keep the original container sealed and desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.