Description

Propargyl-Peg3-Tos is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a tosylate leaving group. This bifunctional linker is critical for click chemistry applications, enabling efficient and selective conjugation of biomolecules, polymers, and small molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for drug discovery, bioconjugation, and the development of novel polymer architectures.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label proteins, peptides, and oligonucleotides.
• Pharmaceutical Linker: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, leveraging the PEG spacer for improved solubility and pharmacokinetics.
• Polymer Functionalization: Acts as a versatile initiator or terminating agent for the synthesis of functionalized PEG-based polymers, hydrogels, and smart materials.
• Surface Modification: Enables the covalent attachment of bioactive molecules to nanoparticles, biosensors, and diagnostic assay platforms.
• Chemical Probe Synthesis: Facilitates the creation of activity-based probes and imaging agents for proteomics and cellular studies.
• Crosslinking Agent: Employed in the preparation of crosslinked polymer networks and biomaterials with tailored properties.

Basic Information

Product Name	Propargyl-Peg3-Tos
CAS No.	1119249-30-7
Molecular Formula	C19H28O7S
Molecular Weight	400.49 g/mol
Synonyms	Propargyl-PEG3-tosylate; 2,5,8,11-Tetraoxatetradec-13-yn-14-yl 4-methylbenzenesulfonate; Propargyl-PEG3-OTs; Propargyl-tri(ethylene glycol) tosylate; 4-Methylbenzenesulfonic acid 2,5,8,11-tetraoxatetradec-13-yn-14-yl ester; Tosyl-PEG3-propargyl; Propargyl-PEG3-OTsylate; Alkyne-PEG3-OTs
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.