Description

H2N-PEG6-CH2COOH is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a carboxylic acid group, separated by a hexaethylene glycol spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the creation of stable, water-soluble linkers for drug delivery systems, diagnostics, and biomaterials. It is essential for researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science who require high-purity, functionalized PEG linkers.

Application

• Bioconjugation reagent for attaching peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules.
• Building block for synthesizing PEGylated drug conjugates to improve solubility, stability, and pharmacokinetics.
• Intermediate in the preparation of functionalized hydrogels and biocompatible polymers for medical devices.
• Crosslinking agent for modifying biomaterial surfaces to enhance cell adhesion or reduce non-specific binding.
• Precursor for synthesizing complex ADC (Antibody-Drug Conjugate) linkers and prodrug systems.
• Tool compound in diagnostic assay development, such as for creating fluorescent or enzymatic probes.

Basic Information

Product Name	H2N-PEG6-CH2COOH
CAS No.	1104083-46-6
Molecular Formula	C17H35NO9
Molecular Weight	397.46 g/mol
Synonyms	6-Amino-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid; Amino-PEG6-acetic acid; Fmoc-N-amido-PEG6-acid; NH2-PEG6-COOH; Amine-PEG6-acid; α-Amino-ω-carboxy hexaethylene glycol; Heterobifunctional PEG6 linker; 2-[2-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
EINECS	Contact for details

Quality Control

Our H2N-PEG6-CH2COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and functional integrity. Certificates of Analysis (COA) with detailed specifications are provided to support your research and cGMP-compliant manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	397.46 ± 2

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.