Description

H2N-Peg24-Tbu is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a tert-butyl ester-protected carboxylic acid. This compound is engineered to serve as a versatile linker and spacer molecule, enabling the controlled conjugation of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require precise, reproducible, and stable cross-linking for applications like drug delivery systems, diagnostic assays, and hydrogel fabrication.

Application

• Bioconjugation & Drug Delivery: As a heterobifunctional crosslinker for attaching peptides, proteins, or antibodies to nanoparticles, drug payloads, or solid supports to create targeted therapeutics and diagnostics.
• PEGylation Reagent: For introducing amine-reactive sites onto molecules or surfaces, followed by deprotection of the Tbu ester to create carboxylic acid functionalities for further coupling.
• Hydrogel & Biomaterial Synthesis: As a building block for creating biocompatible, tunable hydrogels used in tissue engineering, 3D cell culture, and controlled release matrices.
• Surface Functionalization: For modifying gold nanoparticles, quantum dots, or sensor surfaces with amine groups to enhance biocompatibility and enable subsequent biomolecule immobilization.
• Polymer Chemistry: As a macroinitiator or monomer in the synthesis of functional, amphiphilic block copolymers with precise chain lengths.
• Diagnostic Assay Development: In the fabrication of lateral flow assays and ELISA platforms for creating stable capture antibody conjugates.

Basic Information

Product Name	H2N-Peg24-Tbu
CAS No.	1104076-62-1
Molecular Formula	C55H109NO27
Molecular Weight	~1216.5 g/mol
Synonyms	Amine-PEG24-t-butyl ester; α-Amino-ω-(t-butoxycarbonyl)-tetraicosaethylene glycol; Boc-NH-PEG24-COOH; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2-tert-butoxyacetate; Amino-PEG24-t-butyl acetate; Heterobifunctional PEG 24 Amine t-Butyl Ester
EINECS	Contact for details

Quality Control

Our H2N-Peg24-Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and commercial bioconjugation. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight, and functional group assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight Confirmation (MS)	Conforms
Amine Value (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.