Description

Deuterated Atazanivir CAS NO 1092540-56-1 is a stable isotope-labeled analog of the antiretroviral drug atazanavir, where specific hydrogen atoms are replaced with deuterium. This deuteration is critical for enhancing metabolic stability and reducing the rate of drug clearance in pharmacokinetic studies. It serves as an indispensable internal standard in quantitative bioanalytical methods, ensuring accurate and reliable measurement of atazanavir levels in biological matrices. This compound is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and pharmacokinetics (DMPK) research.

Application

• Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of atazanavir in plasma, serum, and other biological fluids.
• Essential for conducting pharmacokinetic (PK) and bioavailability studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of atazanavir.
• Facilitates drug-drug interaction studies by providing a reliable reference for measuring changes in atazanavir concentration when co-administered with other medications.
• Supports clinical trial research and therapeutic drug monitoring (TDM) protocols, ensuring data integrity and regulatory compliance.
• Enables metabolite identification and profiling studies due to its distinct mass shift, aiding in the structural elucidation of drug metabolites.
• Applied in the development and validation of robust bioanalytical assays according to FDA, EMA, and ICH guidelines.

Basic Information

Product Name	Deuterated Atazanivir
CAS No.	1092540-56-1
Molecular Formula	C38H47D5N6O7 (Exact deuterated form may vary; contact for details)
Molecular Weight	Contact for details
Synonyms	Atazanavir-d5; Deuterated Atazanavir Sulfate; BMS-232632-d5; (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioic Acid, Dimethyl Ester, Deuterated; Atazanavir Isotope-Labeled Standard; RC 809-d5; HIV Protease Inhibitor-d5
EINECS	Contact for details

Quality Control

Every batch of our Deuterated Atazanivir is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and absence of critical impurities. Our quality protocols are designed to meet the stringent requirements of GMP/GLP-compliant research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.