Description

-Oxo-3-Pyridinebutyric Acid, n-Hydroxysuccinimide Ester is a high-purity, heterocyclic active ester derivative designed for advanced bioconjugation and peptide synthesis. This compound matters as a critical reagent for forming stable amide bonds under mild conditions, enabling the precise labeling and modification of biomolecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antibody-drug conjugates (ADCs), diagnostic probes, and other sophisticated biopharmaceuticals.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: A key intermediate for covalently attaching cytotoxic payloads to monoclonal antibodies.
• Peptide & Protein Modification: Used for site-specific labeling of peptides, proteins, and enzymes with fluorophores, biotin, or other functional groups.
• Diagnostic Reagent Synthesis: Employed in the production of contrast agents and molecular imaging probes for in vitro and in vivo diagnostics.
• Biomaterial Functionalization: Facilitates the surface modification of polymers, nanoparticles, and hydrogels to introduce bioactive motifs.
• Cross-linking Agent: Acts as a homobifunctional cross-linker for studying protein-protein interactions or creating biomolecular networks.
• Solid-Phase Peptide Synthesis (SPPS): Serves as an activated ester for efficient coupling in automated peptide synthesis.

Basic Information

Item	Detail
Product Name	-Oxo-3-Pyridinebutyric Acid, n-Hydroxysuccinimide Ester
CAS No.	1076199-29-5
Molecular Formula	C13H12N2O5
Molecular Weight	276.25 g/mol
Synonyms	4-Oxo-4-(3-pyridyl)butyric Acid N-Hydroxysuccinimide Ester; 3-Pyridinebutanoic Acid, 4-Oxo-, 2,5-Dioxo-1-pyrrolidinyl Ester; 4-(3-Pyridinyl)-4-oxobutyric Acid N-Succinimidyl Ester; 4-Oxo-4-(pyridin-3-yl)butanoic Acid Succinimidyl Ester; NHS Ester of 4-Oxo-3-Pyridinebutyric Acid; 3-Pyridinebutyric Acid, 4-Oxo-, N-Hydroxysuccinimide Ester; Succinimidyl 4-(3-Pyridinyl)-4-oxobutyrate
EINECS	Contact for details

Quality Control

Our -Oxo-3-Pyridinebutyric Acid, n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.