Description

6-Maleimido-1-Hexanal is a heterobifunctional crosslinking agent featuring a maleimide group and an aldehyde functionality. This compound is essential for creating stable, site-specific conjugations between thiol-containing molecules and amine-containing molecules under mild conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein/peptide chemistry, enabling the precise engineering of therapeutic and diagnostic biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via thiol-maleimide and amine-aldehyde coupling strategies.
• Protein and Peptide Modification: Site-specific labeling or functionalization of proteins, enzymes, and peptides for research, diagnostics, and therapeutic applications.
• Biomaterial and Hydrogel Synthesis: Crosslinking agent for creating functionalized polymer networks and smart biomaterials with tailored biological activity.
• Surface Immobilization: Functionalizing gold surfaces, chips, or nanoparticles with biomolecules for biosensor and diagnostic assay development.
• Enzyme Immobilization: Covalent attachment of enzymes to solid supports for biocatalysis and industrial enzyme applications.
• Fluorescent Probe and Dye Conjugation: Creating stable fluorescent antibody or protein conjugates for flow cytometry, immunohistochemistry, and imaging.

Basic Information

Item	Details
Product Name	6-Maleimido-1-Hexanal
CAS No.	1076198-37-2
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	6-Maleimidocaproaldehyde; Maleimide-C6-CHO; N-(5-Oxopentyl)maleimide; 6-Maleimidohexanal; 1-(6-Oxohexyl)-1H-pyrrole-2,5-dione; 6-Maleimidocapraldehyde; 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanal
EINECS	Contact for details

Quality Control

Our 6-Maleimido-1-Hexanal is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for functional group identification. We provide comprehensive Certificates of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.