Description

(S)-n-Fmoc-A-Methylglutamic Acid 5-tert-Butyl Ester is a high-purity, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is a critical chiral building block, offering precise stereochemical control for the development of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel peptide-based therapeutics and diagnostics. Its protected functional groups ensure compatibility with standard Fmoc solid-phase peptide synthesis protocols.

Application

• Peptide Drug Discovery: A key intermediate for the solid-phase synthesis of constrained or modified peptides with enhanced metabolic stability and receptor selectivity.
• Chemical Biology Probes: Used to incorporate non-natural amino acids into peptides for studying protein-protein interactions and enzyme mechanisms.
• GPCR-Targeted Therapeutics: Essential for constructing peptide libraries targeting G-protein-coupled receptors (GPCRs) for drug screening.
• Diagnostic Agent Development: Serves as a building block for peptide-based imaging agents and contrast media.
• Academic & Industrial Research: Employed in fundamental research on peptide structure-activity relationships (SAR) and folding.

Basic Information

Product Name	(S)-n-Fmoc-A-Methylglutamic Acid 5-tert-Butyl Ester
CAS No.	1072845-48-7
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-A-Me-Glu(OtBu)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpentanedioic acid 5-tert-butyl ester; N-α-Fmoc-α-methyl-L-glutamic acid γ-tert-butyl ester; Fmoc-α-methyl-L-glutamic acid 5-tert-butyl ester; Fmoc-(α-Me)Glu(OtBu)-OH; (S)-N-Fmoc-2-methylglutamic acid 5-tert-butyl ester; (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpentanedioic acid 5-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-A-Methylglutamic Acid 5-tert-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and chiral analysis, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.