Description

5-Bromo-5'-Uridylic Acid Triethylamine Salt is a chemically modified nucleotide derivative, specifically a brominated uridine monophosphate salt. This compound is a critical intermediate in oligonucleotide synthesis, enabling the site-specific introduction of bromine for cross-linking studies and structural probing. It is essential for research and development in pharmaceutical discovery, molecular biology, and biochemistry, particularly for scientists developing novel antisense oligonucleotides, aptamers, and diagnostic probes.

Application

• Oligonucleotide Synthesis: Key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Structural Biology Research: Used to incorporate bromine atoms as heavy atom markers for X-ray crystallography studies of nucleic acid structures.
• Cross-linking Agent: Facilitates UV-induced cross-linking experiments to study nucleic acid-protein interactions and complex formation.
• Antisense & Therapeutic Oligonucleotide Development: Serves as a building block for creating modified oligonucleotides with enhanced stability and binding affinity for therapeutic applications.
• Biochemical Probe Synthesis: Utilized in the manufacture of labeled probes for hybridization assays and diagnostic tools.
• Academic & Industrial R&D: Fundamental reagent for investigating nucleic acid chemistry, function, and drug discovery in both university and biotech laboratory settings.

Basic Information

Product Name	5-Bromo-5'-Uridylic Acid Triethylamine Salt
CAS No.	1061719-00-3
Molecular Formula	C16H27BrN3O9P
Molecular Weight	516.28 g/mol
Synonyms	5-Bromo-UMP Triethylamine Salt; 5-BrUMP TEA Salt; 5-Bromouridine 5'-Monophosphate Triethylammonium Salt; 5-Bromo-2'-deoxyuridine 5'-monophosphate triethylamine salt (common misnomer, verify structure); Uridine, 5-bromo-, 5'-(dihydrogen phosphate), compd. with N-ethylethanamine (1:1); 5-BrUMP; Bromouridylic Acid TEA Salt
EINECS	Contact for details

Quality Control

Our 5-Bromo-5'-Uridylic Acid Triethylamine Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.