Description

(S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-tert-Butoxy)-Guanidino]-Pentanoic Acid is a sophisticated, orthogonally protected arginine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to provide superior control and efficiency in the construction of complex peptides, particularly those containing arginine residues. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of novel therapeutic peptides, peptidomimetics, and biochemical probes. The CAS number for this compound is 1060769-55-2.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the efficient and sequential assembly of peptide chains on resin.
• Pharmaceutical Research & Development: Critical for the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Probe Development: Used to incorporate arginine motifs into fluorescent tags, affinity labels, and other molecular probes for biological studies.
• Combinatorial Chemistry: Serves as a valuable building block in libraries for high-throughput screening to discover new bioactive compounds.
• Glycopeptide & Lipopeptide Synthesis: Enables the construction of complex modified peptides where the arginine side chain must be selectively deprotected.
• Academic & Institutional Research: Supports fundamental studies in peptide chemistry, protein folding, and structure-activity relationships (SAR).

Basic Information

Product Name	(S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-tert-Butoxy)-Guanidino]-Pentanoic Acid
CAS No.	1060769-55-2
Molecular Formula	C38H48N4O8S
Molecular Weight	720.88 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-L-arginine(Pbf)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((((2,2,4,6,7-pentamethyldihydrobenzofuran-5-yl)sulfonyl)((tert-butoxy)carbonyl)amino)amino)pentanoic acid; Fmoc-Arg(Pbf)-OH (Pbf protected); Fmoc-L-Arg(Pbf)-OH; N-α-Fmoc-N-δ-Pbf-L-arginine; Fmoc-Arg(Pbf)-OH peptide synthesis grade
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-tert-Butoxy)-Guanidino]-Pentanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.