Description

m-Peg5-Succinimidyl Carbonate is a heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive N-hydroxysuccinimide (NHS) ester group. This compound is engineered for the efficient and site-specific conjugation of biomolecules, enabling the creation of stable amide bonds under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science, where precise PEGylation is required to enhance solubility, stability, and pharmacokinetic properties.

Application

• Bioconjugation and PEGylation: Primary reagent for attaching PEG chains to peptides, proteins, antibodies, and other amine-containing biomolecules to improve therapeutic profiles.
• Pharmaceutical Development: Used in the synthesis of PEGylated drug conjugates, antibody-drug conjugates (ADCs), and long-acting injectable formulations.
• Diagnostic Reagent Synthesis: Facilitates the labeling of probes, enzymes, and antibodies with PEG linkers for diagnostic assays and imaging agents.
• Biomaterial and Hydrogel Fabrication: Serves as a crosslinker or functionalization agent in the development of biocompatible polymers and scaffolds for tissue engineering.
• Surface Modification: Used to create PEGylated surfaces on nanoparticles, medical devices, and biosensors to impart stealth properties and reduce non-specific binding.
• Life Science Research: A key tool in academic and industrial R&D for studying protein function, drug delivery mechanisms, and biomolecular interactions.

Basic Information

Product Name	m-Peg5-Succinimidyl Carbonate
CAS No.	1058691-00-1
Molecular Formula	C19H33NO11
Molecular Weight	451.47 g/mol
Synonyms	mPEG5-SC; mPEG5-NHS Ester; Methoxy-PEG5-NHS Ester; 5-Amino-3,6,9,12,15-pentaoxaheptadecan-1-oic acid 2,5-dioxo-1-pyrrolidinyl ester; Methoxy Polyethylene Glycol Succinimidyl Carbonate (MW ~250); NHS-PEG5-OMe; O-(2,5-Dioxopyrrolidin-1-yl) O'-methyl undecaethylene glycol carbonate; Amine-reactive PEG derivative
EINECS	Contact for details

Quality Control

Our m-Peg5-Succinimidyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for critical bioconjugation applications. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and MS are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, and dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.