Description

Bocnh-Peg8-Ch2Ch2Nh2 CAS NO 1052207-59-6 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected amine at one terminus and a primary amine at the other, separated by a flexible PEG8 spacer. This compound is engineered to facilitate the controlled conjugation of biomolecules, peptides, or small molecules in pharmaceutical research and bioconjugation applications. It is a critical reagent for scientists in drug discovery, bioconjugate development, and materials science who require precise, stable, and water-soluble crosslinking strategies.

Application

• As a versatile heterobifunctional crosslinker for the site-specific conjugation of peptides, proteins, and antibodies.
• For the synthesis of PEGylated drug conjugates to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• In the development of biomaterials and hydrogels where controlled amine-reactive chemistry is required.
• As a key intermediate in the preparation of targeted antibody-drug conjugates (ADCs) and diagnostic probes.
• For surface functionalization of nanoparticles and other carriers to introduce amine groups for further modification.
• In solid-phase peptide synthesis (SPPS) as a soluble, Boc-protected building block for introducing PEG spacers.

Basic Information

Product Name	Bocnh-Peg8-Ch2Ch2Nh2
CAS No.	1052207-59-6
Molecular Formula	C33H66N2O11
Molecular Weight	666.89 g/mol
Synonyms	1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amine, N-Boc; Boc-NH-PEG8-CH2CH2-NH2; tert-Butyl (2-(2-(2-(2-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamate; Boc-Amine-PEG8-Amine; Boc-N-amido-PEG8-amine; α-Boc-amino-ω-amino-octaethylene glycol; Heterobifunctional PEG8 linker, Boc-amine/amine
EINECS	Contact for details

Quality Control

Our Bocnh-Peg8-Ch2Ch2Nh2 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, this material should be stored in a cool, dry place, ideally at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.