Description

4-Methylumbelliferyl α-L-Idopranosiduronic Acid 2-Sulphate Sodium Salt is a specialized fluorogenic substrate designed for the detection and quantification of specific lysosomal enzyme activities. This compound is critical for research and diagnostic applications requiring high sensitivity and specificity. It is primarily utilized by pharmaceutical researchers, diagnostic kit manufacturers, and academic institutions focused on enzymology and metabolic disease studies.

Application

• Enzyme Activity Assays: A key fluorogenic substrate for measuring the activity of iduronate-2-sulfatase (I2S) in biochemical research.
• Diagnostic Development: Essential raw material in the manufacturing of diagnostic kits for lysosomal storage disorders, such as Hunter syndrome (Mucopolysaccharidosis II).
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize potential therapeutic compounds targeting sulfatase enzymes.
• Biomedical Research: Employed in cellular and tissue-based studies to investigate enzyme kinetics, inhibitor efficacy, and disease pathology.
• Quality Control in Biologics: Serves as a critical reagent for potency testing and quality assurance of enzyme replacement therapies (ERTs).

Basic Information

Product Name	4-Methylumbelliferyl α-L-Idopranosiduronic Acid 2-Sulphate Sodium Salt
CAS No.	1045020-74-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-MU-IdoA-2S Sodium Salt; 4-Methylumbelliferyl α-L-iduronate 2-sulfate sodium salt; I2S Substrate; Iduronate-2-sulfatase fluorogenic substrate; 4-MU-α-L-IdoA-2S; Hunter Syndrome Assay Substrate; Fluorogenic iduronate-2-sulfate
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl α-L-Idopranosiduronic Acid 2-Sulphate Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research and diagnostic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Fluorogenic Activity	Functional in standard I2S assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.