Description

1-Oleoyl-3-Palmitoyl-Rac-Glycero-2-Phosphoethanolamine is a high-purity synthetic phospholipid, specifically a phosphatidylethanolamine (PE), with defined acyl chain composition. This compound is critical for research and development in advanced lipid-based delivery systems due to its role in forming stable, biocompatible membranes. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating liposomes, lipid nanoparticles (LNPs), and model membrane studies.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural lipid for constructing drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Biomimetic Membrane Research: Used to create model cell membranes for studying membrane protein interactions, fusion processes, and lipid bilayer dynamics.
• Pharmaceutical Excipient: Serves as a functional component in advanced parenteral formulations to enhance stability and bioavailability.
• Bioconjugation & Probe Development: The primary amine group on the phosphoethanolamine headgroup provides a site for covalent attachment of targeting ligands, dyes, or other functional molecules.
• Cosmetic & Dermal Delivery Systems: Incorporated into nanocarriers for the topical delivery of active ingredients in cosmetic and dermatological products.
• Cell Culture & Cryopreservation: Used as a supplement in specialized cell culture media and cryoprotectant formulations.

Basic Information

Product Name	1-Oleoyl-3-Palmitoyl-Rac-Glycero-2-Phosphoethanolamine
CAS No.	1035010-98-0
Molecular Formula	C39H76NO8P
Molecular Weight	718.00 g/mol
Synonyms	PE(18:1/16:0); 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-N-palmitoyl; (Rac)-1-Oleoyl-2-palmitoyl-glycero-3-phosphoethanolamine; Phosphatidylethanolamine (18:1-16:0); POPE (palmitoyl-oleoyl-phosphatidylethanolamine); N-Palmitoyl-1-oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine; 1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphoethanolamine (racemic); Glycerophosphoethanolamine lipid derivative
EINECS	Contact for details

Quality Control

Our 1-Oleoyl-3-Palmitoyl-Rac-Glycero-2-Phosphoethanolamine is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and MS to ensure identity, purity, and acyl chain composition. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Phosphorus)	≥ 98% of theoretical
Fatty Acid Composition	Oleoyl (C18:1): ~50%; Palmitoyl (C16:0): ~50%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.