Description

Fluoresceinyl Gabazine, Bromide is a high-purity, fluorescent-labeled derivative of the potent GABAA receptor antagonist, Gabazine. This compound is specifically engineered for advanced neuroscience and pharmacological research, offering a powerful tool for receptor binding studies and imaging applications. It is essential for researchers and developers in the fields of neuropharmacology, diagnostic assay development, and high-throughput screening who require precise, fluorescent probes for studying inhibitory neurotransmission.

Application

• GABAA Receptor Research: A critical fluorescent tracer for competitive binding assays and receptor localization studies in neurological research.
• High-Throughput Screening (HTS): Enables the development of fluorescence-based assays to identify novel modulators of the GABAergic system for drug discovery.
• Cellular Imaging: Used in fluorescence microscopy and confocal imaging to visualize and quantify GABAA receptor distribution and dynamics in live or fixed cells.
• Diagnostic Probe Development: Serves as a key intermediate or reference standard in creating diagnostic kits for neurological disorders.
• Biochemical Pharmacology: Employed in mechanistic studies to understand the interaction kinetics and stoichiometry of ligands with the GABAA receptor complex.
• Academic and Institutional Research: A vital reagent for universities and research institutes conducting fundamental neuroscience and cell signaling studies.

Basic Information

Product Name	Fluoresceinyl Gabazine, Bromide
CAS No.	1024389-03-4
Molecular Formula	C34H28BrN5O7
Molecular Weight	698.52 g/mol
Synonyms	Fluorescein-Gabazine Bromide; 6-((2-((4-(6-Fluoresceinylcarbamoyl)-1-piperazinyl)sulfonyl)ethyl)amino)-3H-xanthen-3-one Bromide; SR 95531 Fluorescein Conjugate; Gabazine Fluorescein Derivative; Fluorescent SR 95531; GABAA receptor antagonist, fluorescent-labeled; Bicuculline-sensitive GABA receptor antagonist, fluorescein conjugate.
EINECS	Contact for details

Quality Control

Every batch of Fluoresceinyl Gabazine, Bromide is manufactured and analyzed under strict quality management protocols to ensure the highest standards of purity and performance for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and fluorescence properties is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under inert atmosphere to maintain optimal stability and fluorescence performance.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Fluorescence Properties	Ex/Em: ~494 nm / ~521 nm (verify in buffer)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.