Description

(R,S)-Norcotinine-Pyridyl-D4 is a stable isotope-labeled analog of the nicotine metabolite norcotinine, specifically deuterated on the pyridyl ring. This compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and precision in mass spectrometry-based analyses. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic developers focused on nicotine metabolism studies, pharmacokinetic profiling, and clinical toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of norcotinine and related alkaloids in complex biological matrices like plasma, urine, and saliva.
• Pharmacokinetic & Metabolism Research: Enables precise tracking of nicotine and cotinine metabolism in pre-clinical and clinical studies.
• Clinical Toxicology & Biomarker Analysis: Supports reliable testing for nicotine exposure, smoking cessation monitoring, and forensic analysis.
• Drug Development & Bioequivalence Studies: Used in assays to understand drug interactions with nicotine metabolic pathways.
• Reference Material for Method Validation: Serves as a certified reference material to validate and calibrate analytical instruments and procedures.

Basic Information

Product Name	(R,S)-Norcotinine-Pyridyl-D4
CAS No.	1020719-70-3
Molecular Formula	C9H8D4N2O
Molecular Weight	164.22 g/mol
Synonyms	Norcotinine-d4 (Pyridyl); 5-(Pyridin-3-yl-d4)-1-methyl-2-pyrrolidinone; 1-Methyl-5-(3-pyridinyl-d4)-2-pyrrolidinone; (Rac)-Norcotinine-3,4,5,6-d4; Deuterated Norcotinine; Norcotinine Internal Standard; Nicotine Metabolite-d4; 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl-d4)-
EINECS	Contact for details

Quality Control

Every batch of (R,S)-Norcotinine-Pyridyl-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, ensuring compliance with the stringent requirements of analytical reference standard applications. Our products are suitable for use in regulated environments under GLP/GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.