Description

n-(4-Methoxybenzyl)Cotinine-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is specifically designed to ensure the utmost accuracy and reliability in quantitative mass spectrometry analyses by correcting for variations in sample preparation and instrument response. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical diagnostics sectors who require definitive results in method development and validation.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the precise quantification of cotinine and related metabolites in complex biological matrices.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in confirmatory testing for nicotine exposure, smoking cessation monitoring, and compliance testing with high specificity and sensitivity.
• Biomarker Research: Facilitates the development and validation of assays for biomarkers related to tobacco use and associated health outcomes.
• Method Development & Validation: Provides a critical reference point for developing robust, reproducible, and regulatory-compliant analytical methods (e.g., LC-MS/MS, GC-MS).
• Quality Control & Assurance: Employed in laboratory proficiency testing and as a system suitability standard to ensure analytical instrument performance and data integrity.

Basic Information

Product Name	n-(4-Methoxybenzyl)Cotinine-D4
CAS No.	1020719-59-8
Molecular Formula	C18H18D4N2O2
Molecular Weight	298.40 g/mol
Synonyms	Cotinine-D4 N-(4-Methoxybenzyl) Derivative; 1-Methyl-5-(3-pyridyl)-2-pyrrolidinone-d4, N-(4-Methoxybenzyl)-; Deuterated n-(4-Methoxybenzyl)cotinine; (S)-Cotinine-d4 N-(4-Methoxybenzyl)amide; Internal Standard for Cotinine-D4; Nicotine Metabolite Internal Standard-D4; 4-Methoxybenzylcotinine-d4; Cotinine N-(p-Methoxybenzyl) Derivative-d4
EINECS	Contact for details

Quality Control

Every batch of n-(4-Methoxybenzyl)Cotinine-D4 is manufactured under controlled conditions and undergoes rigorous analytical characterization to ensure identity, purity, and isotopic enrichment. Our quality protocols are designed to meet the stringent requirements of research and regulated laboratory environments. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.